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Research & Evidence
The national cancer-attributed medical care costs in the United States are substantial and projected to increase dramatically by 2030.
Medical Care Costs Associated with Cancer Survivorship in the United States
Cancer Epidemiology, Biomarkers & Prevention
Sung, Hyuna; Rebecca L Siegel, Philip S Rosenberg, Ahmedin Jemal. "Emerging cancer trends among young adults in the USA: analysis of a population-based cancer registry." Lancet Public Health, February 4, 2019.
Background: Cancer trends in young adults, often under 50 years, reflect recent changes in carcinogenic exposures, which could foreshadow the future overall disease burden. Previous studies reported an increase in early onset colorectal cancer, which could partly reflect the obesity epidemic. We examined age-specific contemporary incidence trends in the USA for 30 common cancers, including 12 obesity-related cancers.
Interpretation: The risk of developing an obesity-related cancer seems to be increasing in a stepwise manner in successively younger birth cohorts in the USA. Further studies are needed to elucidate exposures responsible for these emerging trends, including excess bodyweight and other risk factors.
Berry KM, Fetterman JL, Benjamin EJ, et al. "Association of Electronic Cigarette Use With Subsequent Initiation of Tobacco Cigarettes in US Youths." JAMA Netw Open, February 1, 2019.
This large, nationally representative study of US youths supports the view that e-cigarettes represent a catalyst for cigarette initiation among youths. The association was especially pronounced in low-risk youths, raising concerns that e-cigarettes may renormalize smoking behaviors and erode decades of progress in reducing smoking among youths. Although the individual-level risk of cigarette initiation was comparable for prior e-cigarette users and prior other tobacco product users, the proportion of new cigarette use attributable to prior e-cigarette use appears larger than the proportion attributable to prior use of all other products combined. These findings strengthen the rationale for aggressive regulation of youth access to and marketing of e-cigarettes to achieve future decreases in the prevalence of cigarette use among youths.
Schnoll R, Leone F, Veluz‐Wilkins A,et al. . "A randomized controlled trial of 24 weeks of varenicline for tobacco use among cancer patients: Efficacy, safety, and adherence." Psycho‐Oncology, January 24, 2019.
Continuing to smoke after a cancer diagnosis undermines prognosis. Yet few trials have tested Food and Drug Administration (FDA)‐approved tobacco use medications in this population. Extended use varenicline may represent an effective treatment for cancer patients who smoke given barriers to cessation including a prolonged time line for relapse.
"Cancer Facts & Figures 2019." American Cancer Society, January 8, 2019.
Estimated numbers of new cancer cases for 2019, excluding basal cell and squamous cell skin cancers and in situ carcinomas except urinary bladder. Estimates are not available for Puerto Rico.
Note: State estimates are offered as a rough guide and should be interpreted with caution. State estimates may not add to US total due to rounding.
Siegel, Rebecca L., MPH; Kimbertly D. Miller, MPH; Ahmedin Jemal, DVM, PhD. "Cancer Statistics, 2019." Wiley Online Library, January 8, 2019.
Cancer is a major public health problem worldwide and is the second leading cause of death in the United States. In this article, we provide the estimated numbers of new cancer cases and deaths in 2019 in the United States nationally and for each state, as well as a comprehensive overview of cancer occurrence based on the most current population-based data for cancer incidence through 2015 and for mortality through 2016. We also estimate the total number of deaths averted because of the continuous decline in cancer death rates since the early 1990s and analyze cancer mortality rates by county-level poverty.
U.S. Surgeon General Jerome Adams. "Surgeon General’s Advisory on E-cigarette Use Among Youth." December 18, 2018.
I, Surgeon General of the United States Public Health Service, VADM Jerome Adams, am emphasizing the importance of protecting our children from a lifetime of nicotine addiction and associated health risks by immediately addressing the epidemic of youth e-cigarette use. The recent surge in e-cigarette use among youth, which has been fueled by new types of e-cigarettes that have recently entered the market, is a cause for great concern. We must take action now to protect the health of our nation’s young people.
Patrick, Megan E., PhD; Richard Miech, PhD; Lloyd Johnston, PhD; Patrick M. O’Malley, PhD; Jerald G. Bachman, PhD. "Adolescent Vaping and Nicotine Use in 2017–2018 — U.S. National Estimates." New England Journal of Medicine, December 17, 2018.
A rapid increase in the prevalence of vaping among adolescents has aroused public health concern. Adolescents who “vape” use a device such as an electronic cigarette to inhale a heated aerosol, which typically contains nicotine. In 2017, vaping was the most common use of any tobacco-like product among adolescents.1 This is a rapid rise from a near-zero prevalence of vaping in 2011.2 We assessed whether the prevalence of nicotine vaping increased among adolescents from 2017 to 2018.
Pankaj Parag Sharma, Mark Benden, Ranjana K. Mehta, Adam Pickens & Gang Han . "A quantitative evaluation of electric sit-stand desk usage: 3-month in-situ workplace study." IISE Transactions on Occupational Ergonomics and Human Factors, September 13, 2018.
Sit-stand desk interventions are deployed to reduce sedentary time and improve ergonomic adjustability in modern workplaces, with ultimate goals of improving health and productivity. Sit-stand desks, however, require workers to take an active role in changing the desk position, and usage compliance of the sit-stand function has been a challenge. This study used computer software to objectively record continuous data on electric sit-stand desk usage during computer use, to understand current desk usage behaviors in a large office environment involving ∼300 workers for 3 months. We found that workers completed roughly one desk position change per work day, and one-fourth of the workers always had the desk in a seated position (during computer use). The methods used here demonstrate a novel approach to record sit-stand desk usage continuously during active computer use.
Kuiper NM, Loomis BR, Falvey KT, Gammon DG, King BA, Wang TW, et al. "Trends in Unit Sales of Flavored and Menthol Electronic Cigarettes in the United States, 2012–2016." Centers for Disease Control and Prevention, Preventing Chronic Disease, August 23, 2018.
CDC and RTI International analyzed retail scanner data to assess national and state-specific trends in sales of flavored and menthol e-cigarettes. Findings from this analysis include:
- During 2012-2016, flavored e-cigarette sales as a percentage of all e-cigarette sales rose national from about 2% to nearly 20% in all but four states
- Menthol e-cigarette sales remained stable nationally at 35-40%
- Over half of total e-cigarette sales in 2016 were flavored or menthol products, and sales varied by product type
- Continued monitoring of the variety of flavored tobacco products available in the United States, including combustible, noncombustible, and electronic tobacco products, is critical for informing comprehensive tobacco prevention and control strategies
Wang, Teresa W., PhD; Michael A. Tynan; Cynthia Hallett, MPH; Laura Walpert, JD; Maggie Hopkins; Darryl Konter; Brian A. King, PhD. "Smoke-Free and Tobacco-Free Policies in Colleges and Universities ― United States and Territories, 2017." Morbidity and Mortality Weekly Report (MMWR), June 22, 2018.
Each year in the United States, cigarette smoking causes an estimated 480,000 deaths, including approximately 41,000 deaths from secondhand smoke exposure among nonsmoking adults. Smoke-free policies protect nonsmokers from secondhand smoke exposure, reduce the social acceptability of smoking, help in preventing youth and young adult smoking initiation, and increase smokers’ efforts to quit smoking. Given that 99% of adult cigarette smokers first start smoking before age 26 years and many smokers transition to regular, daily use during young adulthood, colleges and universities represent an important venue for protecting students, faculty, staff members, and guests from secondhand smoke exposure through tobacco control policies
Halpern, Scott D., M.D., Ph.D., Michael O. Harhay, Ph.D., Kathryn Saulsgiver, Ph.D., Christine Brophy, Andrea B. Troxel, Sc.D., and Kevin G. Volpp, M.D., Ph.D.. "A Pragmatic Trial of E-Cigarettes, Incentives, and Drugs for Smoking Cessation." New England Journal of Medicine, June 14, 2018.
BACKGROUND: Whether financial incentives, pharmacologic therapies, and electronic cigarettes (e-cigarettes) promote smoking cessation among unselected smokers is unknown.
CONCLUSIONS: In this pragmatic trial of smoking cessation, financial incentives added to free cessation aids resulted in a higher rate of sustained smoking abstinence than free cessation aids alone. Among smokers who received usual care (information and motivational text messages), the addition of free cessation aids or e-cigarettes did not provide a benefit. (Funded by the Vitality Institute; ClinicalTrials.gov number, NCT02328794.)
Marian Freedman and Michael G Burke, MD. "High-nicotine e-cigarettes lead to more smoking and vaping." Contemporary Pediatrics, February 1, 2018.
Compared with adolescents who use e-cigarettes with relatively low or no nicotine concentrations, those who use e-cigarettes with higher nicotine concentrations are more likely to progress to more frequent and intense combustible cigarette smoking and vaping.
National Academies of Sciences, Engineering, and Medicine. "Incorporating weight management and physical activity throughout the cancer care continuum: Proceedings of a workshop." Washington, DC: The National Academies Press., 2018.
The National Cancer Policy Forum of the National Academies of Sciences, Engineering, and Medicine held a public workshop, Incorporating Weight Management and Physical Activity Throughout the Cancer Care Continuum, on February 13 and 14, 2017, in Washington, DC. The purpose of this workshop was to highlight the current evidence base, gaps in knowledge, and research needs on the associations among obesity, physical activity, weight management, and health outcomes for cancer survivors, as well as to examine the effectiveness of interventions for promoting physical activity and weight management among people living with or beyond cancer. Workshop sessions also reviewed the opportunities and challenges for providing weight management and physical activity interventions to cancer survivors. This publication summarizes the presentations and discussions from the workshop.
Hackshaw, Allan; Joan K. Morris; Sadie Boniface; Jin-Ling Tang, Dušan Milenković,. "Low cigarette consumption and risk of coronary heart disease and stroke: meta-analysis of 141 cohort studies in 55 study reports." The BMJ, January 24, 2018.
Around one billion adults worldwide smoke,1 with high prevalence in developing countries, where 49% of men and 11% of women use tobacco.2 Although the prevalence of current smokers has decreased over time in several countries, the global absolute number of smokers has increased owing to population growth.3 Policies have successfully encouraged people to quit, using aids such as nicotine replacement therapy and electronic cigarettes (e-cigarettes).4
National Academies of Sciences, Engineering, and Medicine. "Public Health Consequences of E-Cigarettes." Washington, DC: The National Academies Press, 2018.
Millions of Americans use e-cigarettes. Despite their popularity, little is known about their health effects. Some suggest that e-cigarettes likely confer lower risk compared to combustible tobacco cigarettes, because they do not expose users to toxicants produced through combustion. Proponents of e-cigarette use also tout the potential benefits of e-cigarettes as devices that could help combustible tobacco cigarette smokers to quit and thereby reduce tobacco-related health risks. Others are concerned about the exposure to potentially toxic substances contained in e-cigarette emissions, especially in individuals who have never used tobacco products such as youth and young adults. Given their relatively recent introduction, there has been little time for a scientific body of evidence to develop on the health effects of e-cigarettes.
Public Health Consequences of E-Cigarettes reviews and critically assesses the state of the emerging evidence about e-cigarettes and health. This report makes recommendations for the improvement of this research and highlights gaps that are a priority for future research.